A Moveable Yeast: modeling shows proteins never sit still
Our body’s proteins – encoded by DNA to do the hard work of building and operating our bodies – are forever on the move. Literally, according to new findings reported by Trey Ideker, PhD, chief of the Division of Genetics in the UC San Diego School of Medicine, and colleagues in a recent issue of the Proceedings of the National Academy of Sciences.
Hemoglobin protein molecules, for example, continuously transit through our blood vessels while other proteins you’ve never heard of bustle about inside cells as they grow, develop, respond to stimuli and succumb to disease.
To better understand the role of proteins in biological systems, Ideker and colleagues developed a computer model that can predict a protein’s intracellular wanderings in response to a variety of stress conditions.
To date, the model has been used to predict the effects of 18 different DNA-damaging stress conditions on the sub-cellular locations and molecular functions of more than 5,800 proteins produced by yeasts. They found, for example, that yeast proteins could move from mitochondria to the cell nucleus and from the endoplasmic reticulum to Golgi apparatus.
Though the model debut involved yeasts, researchers said the coding can be adapted to study changes in protein locations for any biological system in which gene expression sequences have been identified, including stem cell differentiation and drug response in humans.
Image courtesy of Material Mavens
I have fruit polos and lollypops be jealous.
omg do many people not know what fruit polos are? they are heaven
In America, we call them lifesavers. They can be chewy or hard candy.
polos aren’t chewy and they also come in mint.
this week on: britan thinks its special
Because when I was 13 years old, I was sent home for my tank top straps being a little too thin, but a boy could wear a Cool Story babe, Go Make Me A Sandwich shirt and not be looked at twice.
Because when I was 17 and I told a guy “No” and the next day the word tease was painted on my locker.
Because when I was 18 and just wanted to be friends, I was a bitch.
Because I feel the need to say “I have a boyfriend” instead of “No” because guys respect other men more than they would ever respect me.
Because society screams “don’t get raped” instead of “don’t rape”
Because I am scared to walk alone at 10 PM
Because being beautiful is the most important thing I’ll ever do.
Because when I wear my favorite skirt “I’m asking for it”
Because the song Blurred Lines exists
Because no means no no matter how you fucking spin it
Because a girl was drugged and raped with a beer bottle, and the boys who did it are out on bail.
Because I owe you nothing
Because pepper spray is a gift I receive yearly.
Because I am asked if I have a boyfriend more than I am asked about my mental health
Because my clothes say more about my consent then my mouth does.
Because the wage gap exists
Because “not all men are like that” is said way too often
Because I feel the need to say “I’m not a feminist but…”
Because I’m writing this fucking piece